Alzheimer’s creates suffering for 5.1 million people in the United States. The incidence of Alzheimer’s is expected to increase in the next few years. Fortunately, research surrounding the debilitating condition has been vigorous. A short time ago, scientists from the University of British Columbia in Canada published a report detailing their breakthrough in creating medication for Alzheimer’s.
New research from from the university has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer’s disease with an antibiotic called Ceftriaxone. It works by killing bacteria.
An injection of Ceftriaxone is sometimes given before certain types of surgery to prevent infections that may develop after the operation. In new findings, researchers demonstrate a possible target and a potential drug treatment to reduce damage to the brain that occurs in the early stages of Alzheimer’s disease.
Using Ceftriaxone, an FDA-approved antibiotic used to treat bacterial infections, researchers were able to reduce synaptic disruption and clear the lines of neuronal communication in mice.
“This dysfunction in cell communication occurs at a very early stage in the disease, before memory impairment is detectable,” says Dr. Jasmin Hefendehl, , the lead author on the paper. “This makes our discovery particularly interesting, as it opens a window for an early intervention strategy to possibly prevent or delay neuron and memory loss.”